The adipokine preadipocyte factor-1 is downregulated in preeclampsia and expressed in placenta
H Stepan, U Wurst, T Ebert, S Kralisch, A Jank, S Drewlo, S Schrey, U Lössner, M Platz, J Kratzsch, M Blüher, M Stumvoll, M Fasshauer · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Various adipocyte-secreted factors contribute to the development and degree of preeclampsia (PE), a severe systemic complication in pregnancy, increasing the future risk for cardiovascular and metabolic disease in both mother and newborn. The adipokine Pre-adipocyte factor-1 (Pref-1) was recently introduced as an inhibitor of adipogenesis and might play an important role in regulation of PE. Material and methods: Pref-1 was quantified in patients with PE (n = 51) and healthy pregnant controls (n = 51) during pregnancy, as well as 6 months after delivery (study population 1). Furthermore, Pref-1 was i…
