GLP-1 regulates the metabolic response during acute inflammation and predicts outcome in critically ill patients: central role of IL-6
F Kahles, C Meyer, J Möllmann, C Lebherz, HM Findeisen, S Diebold, A Koch, F Tacke, N Marx, M Lehrke · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Purpose: Hypoglycemia is associated with increased mortality in critical illness. The underlying mechanisms for inflammation mediated hypoglycemia remain elusive. Since GLP-1 causes insulin secretion, we hypothesized that GLP-1 may be of relevance for inflammation induced hypoglycemia. Methods and Results: GLP-1 serum levels were found to be 6,9 times higher in critically ill patients (n = 155) vs. healthy controls (n = 134) (p < 0.001) and independently predict unfavorable short- (p = 0.001) and longer term (p = 0.01) mortality. To evaluate potential mechanisms we injected C57Bl6 mice with endotoxin. LPS caused…
