miR-199a and miR-1983 – players involved in Diabetic Retinopathy

Diabetic Retinopathy (DR) is the leading cause of blindness in the industrialized countries and is characterized by progressive alterations in the retinal microvasculature that eventually lead to pathologic proliferation of retinal vessels in response to retinal hypoxia and endothelial dysfunction. microRNAs are small, non-coding RNAs that are key regulators in gene expression by repressing protein synthesis. Since the role of miRNAs in DR is still poorly understood, we investigated the microRNA-expression profile in InsAkita mice (3 M, non-diabetic vs. diabetic, n = 4) using the GeneChip® miRNA 3.0 Array by Aff…