Sustained virologic response to antiviral therapy for chronic Hepatitis C virus infection is associated with regression of liver fibrosis assessed by transient elastography

Introduction: Several data suggest that liver fibrosis is a dynamic process and fibrosis or even early stage of cirrhosis is not irreversible and cellular recovery is possible. Aim of our study was to investigate the effect of pegylated interferon alpha plus ribavirin (P/R) treatment on liver fibrosis progression in patients with chronic HCV hepatitis (CHC). Patients and methods: We performed liver stiffness (LS) measurements by FibroScan (Echosens) on 30 CHC patients before and 24 weeks after the end of treatment (EOT +24). We also followed-up further 15 CHC patients who were not eligible for treatment (because…