Species comparison of interleukin-13 induced airway hyperreactivity in precision-cut lung slices

Interleukin-13 is a key cytokine of asthma and elevated in asthmatics resulting in airway hyperresponsiveness (AHR). AHR is a hallmark of allergic asthma defined as exaggerated bronchoconstriction in response to contractile stimuli. Research for the development of new drugs is mainly based on appropriate in vivo and in vitro models. There is a need for translational models with improved predictivity for human. For comparison of different species we used precision-cut lung slices (PCLS) and assessed IL-13 induced hyperreactivity in PCLS of mice, rats, and humans. PCLS were prepared from Balb/c mice, Brown Norway…