Modulation of immune-mediators from donor lungs using the OrganCareSystem® – a potential mechanism for improved outcome
B Wiegmann, C Falk, B Müller, C Neudörfl, A Akhdar, C Kühn, I Tudorache, M Avsar, A Haverich, G Warnecke · Pneumologie · 2014 · Heft 06
Bibliografische Angaben
Zusammenfassung
Objectives: Release of donor-derived immune mediators (IM), triggering allorecognition and inflammation after transplantation (Tx), may impinge on clinical outcome using warm perfusion of donor lungs (OrganCareSystem®, OCS) or standard cold preservation (SOC). IM were analysed in preservation solutions (PS) and peripheral blood (PB), also clinical outcomes monitored. Methods: IM were quantified in PS and PB at protein level by multiplex-technology at the end of OCS (n = 12) or SOC (n = 9). Donor and recipient demographics and midterm outcomes were analysed. Results: PS concentrations of IL-6, IL-10, IL-16, IFN-g…
