The influence of NFATc1 on the inflammatory tumor environment in pancreatic carcinogenesis

Introduction: Pancreatic ductal adenocarcinoma (PDAC) formation and progression requires constitutive activation of oncogenic Kras. The impact of constitutive Kras activation is not limited on epithelial cell but also participates in the modulation of the tumor environment. Latest studies revealed that even early stages of carcinogenesis are associated with a stromal reaction, characterized by a robust desmoplastic response and recruitment of immune cells. Recent evidence suggests an important role for the inflammatory transcription factor NFATc1 in pancreatic carcinogenesis but its influence on the composition…