Generation of exocrine pancreatic cells from plucked human hair derived induced pluripotent stem cells

Human induced pluripotent stem (iPS) cells can be generated from easily accessible tissues such as skin or plucked hair. In case of applying this tool to patients who are classified into a disease group, it enables the generation of disease-specific iPS cells. iPS cells have proven a significant tool to elucidate pathophysiological mechanisms in various diseases such as diabetes, blood disorders, defined neurological disorders and genetic liver disease. However, differentiation of iPS cells towards the pancreatic lineage remains inefficient and variable. Moreover, current protocols are mostly aiming to generate…