Protein kinase D2 modulates tumor growth and tumor angiogenic programme induced by heat shock protein 90
N Azoitei, K Diepold, S Brobovich, C Brunner, A Rouhi, F Genze, A Becher, H Kestler, J van Lint, G Chiosis, S Fröhling, C Scholl, T Seufferlein · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Heat shock protein 90 (HSP90) serves as an ATP-dependent molecular stabilizer of diverse signaling proteins, including many kinases that are involved in cell proliferation and survival. Protein kinase D2 (PRKD2) is a serine-threonine kinase that belongs to the calcium/calmodulin-dependent protein kinase superfamily. We have recently shown that PRKD2 is a crucial regulator of tumor cell – endothelial cell communication in gastrointestinal tumors. Aim: The aim of this study was to investigate whether HSP90 might contribute to tumor growth and tumor angiogenesis through PRKD2 protein stabilization. Re…
