MetaHeps® – A novel method to assess causality in drug-induced liver injury (DILI)

Background: Drug-induced liver Injury (DILI) is the most common reason für acute liver failure. The idiosyncratic form of DILI is still a diagnosis of exclusion and it may be impossible to identify the culprit drug in patients taking several drugs. MetaHeps® are hepatocyte-like cells generated from peripheral blood exhibiting individual hepatocyte-like functions. Therefore, MetaHeps® could be a valuable tool for the positive diagnosis of individual DILI. Aim: To evaluate in vitro testing using MetaHeps® as a tool to diagnose individual DILI Methods: MetaHeps® of patients with suspected DILI were generated and tr…