Testosterone/dihydrotestosterone ratio as a new biomarker for PCOS
J Münzker, D Hofer, M Ulbing, A Harger, T Pieber, B Keevil, G Brabant, E Lerchbaum, B Obermayer-Pietsch · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Polycystic ovary syndrome is a heterogeneous disease with many different aspects including hyperandrogenism and metabolic disturbances. Clinical phenotypes show different patterns of steroid hormones that have been investigated to some extent. The steroid hormone cascade involves the metabolic activity of different enzymes, e.g. 5alpha-reductase, responsible for the conversion of testosterone (TT) to dihydrotestosterone (DHT). This study intended to determine the 5alpha-reductase activity in PCOS patients by calculating the TT/DHT ratio and to further assess the correlation of this ratio with hormo…
