CareLit Fachartikel

The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a study in 107 patients

M Wallwiener, AD Hartkopf, S Riethdorf, J Nees, FA Taran, B Schönfisch, J Heil, C Sohn, K Pantel, A Trumpp, A Schneeweiss · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09

Dokument
824204
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Jahr
2014
Publikation
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
M Wallwiener, AD Hartkopf, S Riethdorf, J Nees, FA Taran, B Schönfisch, J Heil, C Sohn, K Pantel, A Trumpp, A Schneeweiss
Ausgabe
Heft 09 / 2014
Seiten
–
Erschienen: 2014-09-05 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0034-1388600

Zusammenfassung

Purpose: To retrospectively compare the expression of human epidermal growth factor receptor 2 (HER2) by the primary tumor, metastatic tissue, and circulating tumor cells (CTCs) and to analyze the potential impact of HER2 overexpression by CTCs on progression-free (PFS) and overall survival (OS) of patients with metastatic breast cancer (MBC). Methods: CTC-positive (≥5 CTCs/7.5 ml peripheral blood; CellSearch®, Veridex) MBC patients aged > 18 years starting a new line of systemic treatment during 03/2010 – 07/2013 were eligible for inclusion. HER2 status was determined for CTCs (immunofluorescence) and primary (…

Schlagworte

Geburtshilfe und Frauenheilkunde