Decreased transtyretin and increased IL-10 in postoperative serum of patients with lung adenocarcinoma

Background: Transthyretin (TTR) is a controversial carrier protein involved in nutritional status and with unclear role in oncogenesis. Its level was found to be decreased in the serum of patients with lung cancer, ovarian cancer and advanced cervical and endometrial carcinomas. However the role of TTR in non-small cell lung cancer (NSCLC) has not been elucidated yet. IL-10 is an immunosuppressive cytokine produced by various tumor cells, including lung carcinoma and favor tumor growth by stimulating cell proliferation. Moreover, it is also produced by many effector and T regulatory cells. However, recent studie…