Late onset of disease is associated with poor outcome in patients with primary sclerosing cholangitis

Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease, characterized by sclerosis and destruction of the biliary system. The median onset of PSC varies in different populations, but reaches a climax around the age between thirty and forty. We aimed to analyze disease progression and liver-dependent survival in patients with first diagnosis of PSC after the age of fifty years. Methods: Patients who were admitted to our Department during the time period of 1987 and 2012 with well-defined diagnosis of PSC were analyzed in regard to the onset of the disease. Patients with fir…