Cooperation of Hedgehog and Wnt/β-Catenin signalling in regulation of steroidogenesis in the liver

The idea of personalised medicine was focused over the last years, which lead to a growing interest in sex-specific research. Thereby regulation of steroidogenesis is a central aspect. The liver has multiple functions, which can be realised simultaneously only by zonation. Recent studies showed that Hedgehog (Hh) and Wnt/β-Catenin (Wnt) signalling, two morphogenic pathways commonly associated with embryogenesis, development and cancer are active in adult hepatocytes and act as master regulators of zonation in the adult liver [1]. We investigate the specific role of those pathways in two transgenic mouse models.…