Long-term Riociguat administration reduces right heart size in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: a retrospective single-center ana…

Background: Riociguat has been shown to improve exercise capacity in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTPEH). However, the effects of Riociguat on right ventricular (RV) and right atrial (RA) size have not been assessed so far. The aim of this study was to evaluate the change of right heart size and function assessed by echocardiography and right heart catheterization in patients who received Riociguat. Methods: We assessed patients that received Riociguat in our centre within the trials PATENT, PATENTplus, EAS and CHEST. Echocardiography including RV and R…