Repeated controls of gestational angiogenic biomarkers in high-risk pregnancies – do they derive a clinical benefit?

Problem Statement: Pathogenesis of severe placenta mediated gestational complications (preeclampsia, eclampsia, HELLP-Syndrome, abruption of placenta, IUGR) are associated with altered angiogenic biomarker levels. Aim of this study is to determine if maternal serum angiogenic biomarker ratio (sFlt1/PIGF) can predict maternal and/or fetal, neonatal complications during pregnancy. Methods: We prospectively studied 94 women with high-risk pregnancies (previous preeclampsia/eclampsia/HELLPSyndrom, preexisting hypertension, thrombophilia, antiphospholipid-syndrom). We measured serum levels of sFlt-1 and PLGF by ELISA…