CareLit Fachartikel
Hyperglycemic memory – Mechanisms relevant to the diabetic retina
P Friedrichs, T Linn, A Dietrich, G Molema, HP Hammes · Diabetologie und Stoffwechsel · 2015 · Heft 04
Dokument
825027
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Clinical and experimental evidence suggests that hyperglycemic memory is part of the complex pathogenesis of diabetic retinopathy. Perpetuation of oxidative stress, irreversible accumulation of AGEs and hyperglycemia-induced epigenetic changes are possible underlying mechanisms. In the present study we address the gap between cellular memory experiments, reflecting days, and animal and human disease, representing years. STZ (140 mg/kg/body weight) induced diabetic C57Bl6 mice (n = 4 – 6/group) with a hyperglycemia (30 mmol/l) duration of 12 weeks were utilized (DC12W; NC12W = Control). Group B12W was treated in…
Schlagworte
After
Diabetic Retinopathy
Movement
Address
Transplantation
Diabetologie und Stoffwechsel
