L-Carnosine attenuates the development of diabetic nephropathy in the BTBR ob/ob mouse model
T Albrecht, M Schilperoort, S Zhang, BK Krämer, W Kriz, J Van den Born, H Baelde, E De Heer, BA Yard, SJ Hauske · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Diabetic nephropathy (DN) is the most frequent cause for end-stage renal failure (ESRF) worldwide. It's pathophysiology is multi-factorial and current therapeutic options only retard the progression of DN. We hypothesize that L-Carnosine, a natural anti-oxidant and pH-stabilizing dipeptide, may be an alternative therapeutic compound for preventing or retarding the development of DN. Male BTBR ob/ob mice (n = 15) were supplemented with L-Carnosine (4 mmol/l) for 18 weeks. Fasting plasma glucose (FPG), weight and drinking volume were determined weekly. At week 24, blood and urinary samples were collected. All mice…
