Effects of the gestational diabetes-risk polymorphism rs10501320 of MADD gene on metabolic phenotype and glucose homeostasis in women with history of gestational diabetes
N Perakakis, L Arend, L Potasso, A Lamprinou, E Polyzou, A Kassanos, R Rasenack, G Päth, J Seufert, K Laubner · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Objective: We have recently reported that the insulin-biosynthesis-impairing MADD rs10501320 genetic polymorphism is associated with gestational diabetes (GDM) in a European population. Aim of our study was to investigate the effects of this polymorphism on metabolic phenotype and glucose homeostasis in the same population of women 8 – 12 years after pregnancy. Methods: We have previously genotyped the G/C polymorphism, rs10501320 in 157 unrelated women with a history of GDM (Germans = 108, Greeks = 49). The women from the German arm were invited 8 – 12 years after pregnancy to participate in a prospective study…
