Circulating betatrophin is increased in type 2 and gestational diabetes mellitus
S Kralisch, T Ebert, U Wurst, A Hoffmann, U Lössner, J Kratzsch, M Blüher, M Stumvoll, A Tönjes, M Fasshauer · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Objective: Betatrophin has recently been introduced as a novel adipokine/hepatokine which promotes pancreatic β cell proliferation and improves glucose tolerance in several mouse models of insulin resistance. However, regulation of betatrophin in subjects with diabetes mellitus in vivo and in adipocytes in vitro has not been thoroughly determined. Design and Methods: Circulating betatrophin was quantified by ELISA in patients with type 2 diabetes mellitus (T2DM) and in women with gestational diabetes mellitus (GDM) as compared to controls. Moreover, the effects of insulin resistance-inducing hormones and differe…
