Intratumoral Heterogeneity in high grade serous pelvic cancer: Comparing pelvic and omental tumor and lymph node metastases

Background: Recent research has suggested intratumoral heterogeneity in ovarian carcinoma. Additionally, different histologic growth patterns have been described in high grade serous pelvic cancer. Recent definition of molecular subtypes in high grade serous pelvic cancer have suggested that peritumoral desmoplastic response, inflammatory response and proliferative activity (ki-67) as well as the expression of EMA (used as a surrogate marker for MUC-1) may be discriminatory. Methods: Within a preliminary study we have evaluated 12 cases and compared histologic growth pattern, the grade of peritomoral desmoplasti…