Safety and efficacy of Interferon//Ribavirin free therapy in Septuagenerians and Octogenerians with chronic Hepatitis C
R Stern, C Freissmuth, K Kozbial, S Hametner, R Al-Zoairy, S Moser, H Laferl, R Stauber, H Zoller, A Maieron, W Vogel, M Gschwantler, H Hofer, P Ferenci · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Direct acting antivirals (DAA) have revolutionized treatment of chronic hepatitis C. Renal and hepatic function decreases in elderly patients and therefore pharmacokinetics of various drugs may differ in comparison to younger population. In addition, elderly people may suffer from diverse medical conditions requiring long-term treatment and drug-drug interactions with DAA may occur. Octo- and septuagenarians are not included in clinical studies and therefore data on efficacy and safety of IFN-free treatments in elderly are missing. Background and Aims: We included 34 cirrhotic patients > 70 years (…
