Histological characterization of traditional serrated Adenomas compared to conventional Adenomas

Background: Among the recently described and more rapidly progressing colorectal serrated lesions traditional serrated adenoma (TSA) is the rarest subtype. The morphologic distinction between TSA and conventional adenoma, especially villous/tubulovillous adenoma (VA/TVA), may be difficult, because there is a significant histological overlap between these lesions. According to the literature, there are three characteristic features usually present in TSAs: ectopic crypt foci (ECF), luminal serration and typical cytology with columnar epithelial cells with eosinophilic cytoplasm and elongated, centrally placed nuc…