Comparison of sessile serrated adenoma (SSA) histopathologic diagnostic criteria and their effect on reclassification rate of microvesicular hyperplastic polyps to SSA

Background: During the past two decades sessile serrated adenomas (SSA) received considerable attention due to their increased risk of leading to colorectal carcinoma (CRC). CRCs arising from SSA have frequently been associated with interval cancers (those arising after negative colonoscopy). Diagnosis of these lesions can be challenging, as both macroscopic and microscopic features show similarities to microvesicular hyperplastic polyps (MVHP). Since there is almost no malignant potential of MVHP, it is critical to distinguish them from SSA in order to determine the appropriate follow up. Aims: The aims of our…