CareLit Fachartikel
Notch ligands stimulate immune regulatory mechanism of inflammatory cells in PAH
K Watzinger, CM Kähler · Pneumologie · 2015 · Heft 05
Dokument
825204
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Besides vasoconstriction and in situ thrombosis, “vascular remodelling” is a key feature of pulmonary arterial hypertension (PAH). This process is comprised of cellular hypertrophy, cell proliferation in the intima and media of vessels involved. An increased accumulation of T- and B-lymphocytes as well as of macrophages was observed in plexiform lesions and in the remodelled artery walls. Furthermore, elevated levels of pro- and anti-inflammatory cytokines, e.g. IL-6, IL-10, and TNF-α can be found. Additionally, an increase of Notch1 and JAG-1 in pulmonary arteries has been observed. The aim of this study was to…
Schlagworte
Cytokines
B-Lymphocytes
Atmosphere
Arteries
Cytokine
Affect
Blood
Pneumologie
