Characterization of Vitamin D Receptor Expression in Breast Cancer Cells Lines

Background/objectives: In recent years, preclinical and clinical studies suggested that optimal vitamin D status has a protective effect against development of breast cancer. Vitamin D exerts its activity by binding to the vitamin D receptor (VDR). In addition to steroid hormones receptors (eg estrogen and progesterone receptors), other nuclear receptors, such as VDR, are expressed in normal breast tissue and breast tumors. VDR expression can become a new prognosis biomarkers of breast cancer and the balance of vitamin D levels may improve patient prognosis and therapy efficiency. The goal of this research is th…