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Pulmonary allergen clearance is impaired by airway surface dehydration

M Hagner, S Schmidt, E Maier, S Christochowitz, M Lampe, MA Mall, B Fritzsching · Pneumologie · 2015 · Heft 07

Dokument
825333
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
M Hagner, S Schmidt, E Maier, S Christochowitz, M Lampe, MA Mall, B Fritzsching
Ausgabe
Heft 07 / 2015
Seiten
–
Erschienen: 2015-07-14 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0035-1556620

Zusammenfassung

Introduction: Efficient clearance of inhaled allergens from the lungs of patients with allergic asthma is important to avoid prolonged allergen exposure and asthma exacerbation. We hypothesized that impaired mucociliary clearance constitutes a risk factor for inefficient intrapulmonary allergen clearance. Thus, we analyzed allergen clearance mechanisms in wild type (WT) mice and in mice with airway-specific overexpression of the sodium channel ENaC (βENaC-Tg), which suffer from airway surface dehydration, impaired mucociliary clearance and chronic airway inflammation (Mall et al., Nat Med., 2004). Methods: Mucoc…

Schlagworte

Dehydration Asthma Antigen-Presenting Cells Bronchoalveolar Lavage Aspergillus fumigatus Dendritic Cells Aspergillus Allergens After Pneumologie