CareLit Fachartikel

Alpha-1 antitrypsin inhibits ATP-induced release of IL-1β in human monocytes via a cholinergic pathway

R Siebers, S Wilker, M Küllmar, N Aggarwal, A Zakrzewicz, W Padberg, S Janciauskiene, V Grau · Pneumologie · 2015 · Heft 07

Dokument
825334
CareLit-ID
Jahr
2015
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
R Siebers, S Wilker, M Küllmar, N Aggarwal, A Zakrzewicz, W Padberg, S Janciauskiene, V Grau
Ausgabe
Heft 07 / 2015
Seiten
–
Erschienen: 2015-07-14 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0035-1556630

Zusammenfassung

Introduction: In human monocytes, activation of the P2X7 receptor leads to inflammasome assembly and activation of caspase 1 (casp-1). Active casp-1 can cleave pro-IL-1β, which then leads to release of IL-1β, an important mediator of inflammation. Alpha-1 antitrypsin (AAT), a major antiprotease of the lung, exerts anti-inflammatory functions via poorly defined pathways. We hypothesize that AAT inhibits inflammasome-dependent release of IL-1β in monocytes. Materials and Methods: Primary human monocytes or LPS-primed U937 cells were stimulated with 2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphate (BzATP) to ac…

Schlagworte

Alpha-1-Antitrypsin alpha 1-Antitrypsin Acetylcholine Adenosine Caspase 1 Calcium Lead Pneumologie