CareLit Fachartikel

EpCAM-independent enrichment approach for isolation of circulating tumor cells (CTCs) in breast cancer

H Schneck, B Gierke, M Pawlak, M Templin, T Fehm, D Niederacher, H Neubauer · Geburtshilfe und Frauenheilkunde · 2015 · Heft 08

Dokument
825633
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
H Schneck, B Gierke, M Pawlak, M Templin, T Fehm, D Niederacher, H Neubauer
Ausgabe
Heft 08 / 2015
Seiten
–
Erschienen: 2015-08-27 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0035-1560010

Zusammenfassung

Background and Objectives: CTCs are essential for establishing metastasis in breast cancer. While many assays currently exist for the enumeration of CTCs, limitations include the reliance on the expression of the cell surface marker epithelial cell adhesion molecule (EpCAM) (e.g. CellSearch® system). These approaches may omit CTCs expressing either no or low levels of EpCAM, eventually representing the metastasis-initiating population. In order to successfully capture EpCAM-negative or -low breast cancer cells we have tested different antibodies specific for surface proteins and extracellular matrix (ECM) compon…

Schlagworte

Breast Antibodies Tumor Blood Population After Geburtshilfe und Frauenheilkunde