Crucial role of the interplay of the MAPKAP kinases 2 and 3 for LPS-induced inflammation and their relevance for liver pathogenesis

The liver plays a pivotal role in innate and adaptive immunity as it is frequently exposed to pathogens reaching the liver via the blood flow. It is important for the production of acute phase proteins, among others soluble pattern-recognition receptors and components of the complement system, which are important constituents of innate immunity. Moreover, the liver harbors the largest pool of resident tissue macrophages. They play a key role for the elimination of opsonized immune complexes by phagocytosis and they are important sources of inflammatory cytokines, which induce acute phase protein production in he…