CareLit Fachartikel

Expression, epigenetical regulation and signaling network of embryonic stem cell-expressed RAS in hepatic stellate cells

S Nakhaei-Rad, H Nakhaeizadeh, S Götze, C Kordes, D Häussinger, MR Ahmadian · Zeitschrift für Gastroenterologie · 2015 · Heft 12

Dokument
825777
CareLit-ID
Jahr
2015
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
S Nakhaei-Rad, H Nakhaeizadeh, S Götze, C Kordes, D Häussinger, MR Ahmadian
Ausgabe
Heft 12 / 2015
Seiten
–
Erschienen: 2015-12-14 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0035-1567950

Zusammenfassung

Hepatic stellate cells (HSC) are liver-resident mesenchymal stem cells with progenitor characteristics. HSCs are activated during liver injury and are involved in pivotal processes e.g. liver development, immunoregulation, regeneration and also fibrosis [1,2]. To date, several controversial studies reported the candidate pathways that regulate the plasticity of HSC towards distinct physiological and pathophysiological processes. Here we analyzed the expressional changes and activity of small GTPases of the RAS family, and investigated the signaling networks of quiescent HSC versus activated HSC. For the first ti…

Schlagworte

Cells Hepatic Liver Quiescent Activation Signaling Embryonic Cell-Expressed Stellate Activated Kordes Progenitor Zeitschrift für Gastroenterologie