WISP1 modulates immune cell infiltration upon drug-induced liver injury (DILI)

Multiple potentially harmful stimuli challenge the liver, the chief metabolic and detoxifying organ of the body. Administration of hepatotoxic chemicals (e.g., CCl4, APAP) can induce the loss of liver mass which may lead to fatal conditions such as acute liver failure, or to chronic pathological conditions such as fibrosis, cirrhosis and hepatocellular carcinoma. Drug metabolites cause direct cell stress, trigger specific inflammatory response which removes tissue debris, followed by the regenerative response. However, an excessive inflammatory response can lead to a dramatic aggravation of the existing injury.…