CareLit Fachartikel
Differential regulation of G-protein coupled bile acid receptor (Gpbar-1) by Sp1/KLF5 family transcription factors
C Chintalapati, C Wöhler, C Ehlting, J Bode, D Häussinger, V Keitel · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Dokument
825781
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Jahr
2015
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Zusammenfassung
TGR5 (Gpbar-1) is a G-protein coupled bile acid receptor, which is highly expressed in cholangiocytes, liver sinusoidal endothelial cells, liver macrophages and CD14 positive monocytes of peripheral blood. TGR5-/- mice show impaired liver regeneration after partial hepatectomy and the increased inflammation in liver disease models, thus emphasizing a protective role of TGR5 in liver. While TGR5 functions are being studied extensively, little is known about the transcriptional regulation of this receptor. Aim: To investigate the mechanism and transcriptional regulation of TGR5. Methods: The potential TGR5 promote…
Schlagworte
Chromatin Immunoprecipitation
Chromatin
Apigenin
Blood
After
Zeitschrift für Gastroenterologie
