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Deficiency of calcium-independent phospholipase A2 beta with aging causes biliary epithelial ductular reaction associated with increased bile acids in enterohepatic circulation

L Jiao, H Gan-Schreier, W Wei, S Tuma-Kellner, W Stremmel, W Chamulitrat · Zeitschrift für Gastroenterologie · 2015 · Heft 12

Dokument
825785
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
L Jiao, H Gan-Schreier, W Wei, S Tuma-Kellner, W Stremmel, W Chamulitrat
Ausgabe
Heft 12 / 2015
Seiten
–
Erschienen: 2015-12-14 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0035-1568030

Zusammenfassung

Background/Aims: Calcium-independent phospholipase A2 beta (iPLA2beta) generates lysophosphatidylcholine which is recognized as a macrophage 'fine me' signal for removal of apoptotic cells. We have shown that iPLA2beta deficiency causes an accumulation of apoptotic hepatocytes associated with a decrease of serum and hepatic lipids including cholesterol. We here determined whether iPLA2beta deficiency in aged mice can result in abnormalities in the hepatobiliary system and the alterations of bile acid contents. Methods: Control (WT) and whole body male iPLA2beta-/- mice at 19 – 22 months old were used. Bile acid…

Schlagworte

Aged Cholesterol Bacteria Calcium Deoxycholic Acid Chromatography Aging Lead Actin Zeitschrift für Gastroenterologie