The impact of the interaction between Embryonic stem cell-expressed Ras and Arginase-1 in hepatic stellate cells

Embryonic stem cell-expressed Ras (ERAS) represents a unusual member of the Ras family with remarkable characteristics in quiescent hepatic stellate cells (HSC).1 ERAS contains a unique N-terminal extension (38 amino acids) upstream of its guanosine triphosphate binding domain, which exhibits remarkable sequence deviations between human and rat species. However, the function of such an additional region with various motifs [1], which is not found in other classical Ras proteins (e.g., HRAS, KRAS and NRAS), remained unclear. Comparative proteome analysis revealed that ERAS is associated with 51 proteins (10 with…