CUX1 in liver cancer: experimental study in hypoxia model
S Blümel, G Metzger, E Hofmann, J Hänze, T Gress, D Bartsch, P Di Fazio, T Wissniowski · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Background: CUX1 (CUTL1) is a transcription factor able to promote the expression of several genes implicated in cellular proliferation, differentiation and demise. In normal adult cells, it preferentially favors the expression of proapoptotic genes. Its aberrant expression in tumor turns its role as foe. It favors the expression of oncogenes and survival factors, especially in stress condition, thus supporting tumorigenesis. Here, we show CUX1 activity during hypoxia in liver cancer cells. Materials/Methods: CUX1was knocked down and its targets were analysed by RT-qPCR in HepG2 and Hep3B cells under hypoxic and…
