Lack of HBeAg does not induce stronger enhancement of innate immunity genes in humanized mice
S Luft, CM Bremer, T Volz, PL Seiz, L Allweiss, K Giersch, J Petersen, AW Lohse, M Lütgehetmann, D Glebe, M Dandri · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
The HBeAg of HBV was reported to counteract immune responses whereas the precore mutation G1896A, which abolishes HBeAg production, has been associated with increased HBV replication. Nevertheless, the role of HBeAg in the HBV life cycle in vivo and its capacity to modulate the expression of antiviral innate signaling pathways remains unclear. Aim of the study was to investigate HBV infection kinetics, replicative activity and expression of innate immunity genes in humanized mice infected with virions lacking HBeAg expression in comparison to wild type (wt) virus. Methods: Mice with comparable levels of human li…
