Case report: GATA-2 deficiency and secondary alveolar proteinosis (AP)

After suffering from various infections (mainly pneumonias) since 2007, in 2014 GATA-2 deficiency was diagnosed in a middle-aged female patient (pt). In 2015 the pt was hospitalized with increasing exertional dyspnea and signs of infection (fever, elevated C-reactive protein). Lung function test showed moderate restriction with mildly reduced CO-diffusion capacity. The differential blood count of the peripheral blood (pb) detected less than 300 lymphocytes/µl. CT scan of the chest showed ground-glass infiltrates. Supposing an underlying organizing pneumonia various microbiological, virological and fungal tests (…