Parameter of glucose metabolism and glucocorticoidal genes from two different human fat depots

The adipose and diabetic epidemic is increasing worldwide, but mechanisms behind remain widely not clear yet. One question which has to be clarified is the impact of different fat depots as putative “metabolic key players”. We investigated 20 obese women. All participants received an extensive phenotyping including oral glucose challenge and euglycemic hyperinsulinemic clamp. Thus, estimates of myocellular and whole body insulin sensitivity were evaluated. Moreover expression levels of genes involved in the glucocorticoid metabolism (11beta-HSD1, glucocorticoid receptor alpha (GRa) and beta (GRb) and H6PDH) were…