Slc13a5/mINDY inhibition prevents diet-induced non-alcoholic fatty liver disease in mice and rats
S Brachs, AF Winkel, H Tang, AL Birkenfeld, H Glombik, A Dudda, B Brunner, K Jahn-Hofmann, D Margerie, AW Herling, H Ruetten, D Schmoll, J Spranger · Diabetologie und Stoffwechsel · 2016 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: Non-alcoholic fatty liver disease (NAFLD) is a world-wide health concern and risk factor for cardio-metabolic diseases. Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotransporter solute carrier family 13 member 5 (SLC13A5, mINDY). Genetic deletion in mice protected from diet-induced adiposity and insulin resistance. Here, we investigated the effects of inducible and/or liver-specific inactivation of mINDY in two independent rodent models. We hypothesized that hepatic mINDY inhibition can prevent the development of fatty liver and he…
