CareLit Fachartikel

Islet Hyperplasia and Hyperghrelinemia in p27 deficient (MENX) rats

T Wiedemann, M Bielohuby, TD Müller, M Bidlingmaier, NS Pellegata · Diabetologie und Stoffwechsel · 2016 · Heft 04

Dokument
825958
CareLit-ID
Jahr
2016
Publikation
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Metadaten
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
T Wiedemann, M Bielohuby, TD Müller, M Bidlingmaier, NS Pellegata
Ausgabe
Heft 04 / 2016
Seiten
–
Erschienen: 2016-04-19 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0036-1580920

Zusammenfassung

Aim: MENX is a spontaneous multiple endocrine neoplasia syndrome in the rat. Affected rats develop pancreatic islet hyperplasia. We wanted to characterize the phenotype of MENX rats concerning fat and glucose metabolism. Methods: We performed histological and immunohistochemical analysis of the endocrine pancreas. Blood plasma of mutant and wild-type rats at different ages was analyzed for various metabolites (Unacylated Ghrelin [UAG], Acylated Ghrelin [AG], Triglycerides, Cholesterol). Additionally, body weight, food intake, body-fat composition and changes in glucose metabolism (oGTT, i.p.GTT, i.p.ITT) of muta…

Schlagworte

Diabetologie und Stoffwechsel