CareLit Fachartikel

Schwann cells secrete factors that impair neuroblastoma growth

T Weiss, S Taschner-Mandl, H Dodig, F Rifatbegovic, C Frech, IM Ambros, PF Ambros · Klinische Pädiatrie · 2016 · Heft 05

Dokument
826071
CareLit-ID
Jahr
2016
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
T Weiss, S Taschner-Mandl, H Dodig, F Rifatbegovic, C Frech, IM Ambros, PF Ambros
Ausgabe
Heft 05 / 2016
Seiten
–
Erschienen: 2016-05-02 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0036-1582510

Zusammenfassung

Background: Spontaneous maturation of neuroblastomas (NB) occurs in 10 – 15% and results in Schwann cell (SC) stroma-rich tumors, i.e. in ganglioneuroblastomas and ganglioneuromas. Previous studies have demonstrated the SC stroma being of non-neoplastic origin in these non-aggressive NBs. The presence of this specific micro-environment in favorable NBs, the knowledge on neuronal-SC interactions in developmental and patho-physiological processes and preliminary NB-SC in vitro data suggest a tumor-inhibiting effect of the SC. Nevertheless, SC-NB interactions are still poorly understood. Methods: In vitro co-cultiv…

Schlagworte

Klinische Pädiatrie