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Pruritus during anti-HCV treatment with PTV/r/OBV+/-DSV is associated with increased bile acid levels.

R Stauber, G Fauler, F Rainer, A Posch, A Streit, W Spindelböck, V Stadlbauer, H Mangge · Zeitschrift für Gastroenterologie · 2016 · Heft 05

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826117
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Jahr
2016
Publikation
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Stauber, G Fauler, F Rainer, A Posch, A Streit, W Spindelböck, V Stadlbauer, H Mangge
Ausgabe
Heft 05 / 2016
Seiten
–
Erschienen: 2016-05-11 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0036-1584070

Zusammenfassung

Introduction: Interferon-free anti-HCV treatment with paritaprevir/ritonavir + ombitasvir +/- dasabuvir (PTV/r/OBV+/-DSV) is highly effective and well-tolerated with only minimal side effects. However, pruritus has been observed in phase III trials in up to 20% of patients and seems to be unique for this DAA combination. The aim of this study was to investigate the effect of PTV/r/OBV+/-DSV on bile acid levels and to relate them to the emergence of pruritus during this treatment. Methods: Patients with chronic hepatitis C genotype 1 or 4 were treated for 12 – 24 weeks with PTV/r/OBV+/-DSV with or without ribavir…

Schlagworte

Zeitschrift für Gastroenterologie