Synergy Research: Investigating the combined action of chamomile, myrrh and coffee charcoal on chemokine release of activated human macrophages

Background: The herbal medicinal product Myrrhinil-Intest®, a combination of myrrh, chamomile flower extract and coffee charcoal is used for the treatment of gastrointestinal complaints. Clinical data suggest its use for the maintenance therapy of inflammatory bowel disease [1]. In vitro studies revealed, that chemokine signaling of human macrophages is influenced by the plant extracts as part of an anti-inflammatory strategy. However, the occurrence of synergistic effects remains unexplored. Aim: The present study aims to investigate the combined effect of the plant extract on chemokine (CXCL13 release) from ac…