Human macrophages differentially express long non-coding RNAs upon polarization

Introduction: Macrophage polarization is a key feature of innate immunity. This inherent versatility of macrophage subtype manifestation helps the host immune system to adapt to changing requirements in the course of defence against pathogens, but it also poses a risk. Inappropriate polarization can lead to a skewed and detrimental immune response. The complex process of macrophage polarization thus needs to be tightly controlled. A newly emerging type RNAs, the long non-coding RNAs, influence cellular processes. Unlike microRNAs, lncRNAs have no defined mode of action, but can exert their function in a plethora…