The influence of the probiotic compound D-Tryptophan on the differentiation of murine naïve CD4+ spleen cells

Introduction: Current therapies for asthma improve symptoms but cannot cure the disease or its prevalence prompting demands for alternatives. The use of probiotic bacteria to prevent chronic diseases could represent a cost-effective approach. However, clinical studies have shown contradictory findings, possibly explained by the individual and highly complex interaction between probiotics and host. To reduce this complexity, our group investigates the use of isolated probiotic compounds, instead of living bacteria. Recently we identified D-Tryptophan (D-Trp) showing immune modulatory properties. As a next step we…