The effect of the antiinflammatory IL-1R antagonist anakinra in mice with CF-like lung disease and Pseudomonas aeruginosa infection

Introduction: Spontaneous neutrophilic inflammation can be triggered by hypoxic epithelial necrosis in mucus-obstructed airways via the release of IL-1a in Scnn1b-Tg mice with CF-like lung disease, as recently reported. In this model, the inhibition of the IL-1R-MyD88 pathway with the IL1-R antagonist anakinra reduced airway neutrophilia and structural lung damage (Fritzsching B. et al., AJRCCM 2015). However, effects of anakinra on airway inflammation and antibacterial host defense in the context of a Pseudomonas infection remain unknown. Thus, the aim of this study was to evaluate the effects of anakinra on ne…