Expression of nuclear hormone receptors in ovarian cancer
C Göß, S Heublein, C Sattler, T Kolben, TM Kolben, M Burgmann, D Mayr, J Gallwas, A Burges, S Mahner, U Jeschke, N Ditsch · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Introduction: Advanced ovarian cancer (OC) has an unfavourable prognosis and limited response to systemic therapeutic agents. Previous work observed an overexpression of LH- and FSH-receptors with high prognostic significance. In the current analysis, we focus on members of the nuclear superfamily (TR (thyroid receptor) α and β, VDR, RXR, PPARγ) to evaluate their expression on tumor tissue and correlate it with immunohistochemical findings and prognosis. Methods: Tissue samples were taken intraoperatively from ovarian cancer patients (n = 154) and immunhistochemical stainings (ABC method) were performed. SPSS wa…
