Prurified anti-trophoblast antibodies (ATAB) suppress the secretion of human Chorionic Gonadotropin (hCG) and stimulate that of Plaminogen-Activator-Inhibitor Type 1 (PAI-1) in JE…
Y Ye, M Vogel, P Burger, N Rogenhofer, S Mahner, U Jeschke, CJ Thaler, V von Schönfeldt · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: ATAB are significantly more prevalent in recurrent miscarriage (RM) patients compared to controls1. Sera of ATAB-positive RM patients inhibit hCG secretion by JEG-3 cells in vitro and show higher concentrations of PAI-1 compared to ATAB-negative sera and healthy controls. We investigated the effect of purified IgGs from RM patients on the hCG and PAI-1 production of JEG-3 cells to further elucidate the precise pathomechanism by which ATAB interferes with early gestation. Study design: IgGs were purified from RM patients with and without ATAB (n = 10 each) using a NAb Protein A/G Spin Columns. Methods…
